Association of Alkaline Ionized Water Apparatus
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About alkaline ionized water apparatus
Research results for alkaline ionized water
Although research into alkaline ionized water began around 1931, it was not until the establishment of the Alkaline Ionizer Review Committee in 1993 that investigations and research from various aspects based on experimental planning were able to proceed.
As a result, the various benefits and functions of alkaline ionized water and the further possibilities it possesses are being gradually explained.
In this section, the results of research performed until now are summarized and the "functions" possessed by alkaline ionized water are introduced.
Intestinal fermentation suppression effect (Research conducted by Food Science Course, Faculty of Agriculture, Gifu University)
Calcium absorption effect (Research conducted by Graduate School of Medicine, Faculty of Medicine, Kyoto University)
Gastric mucous membrane damage suppression effect (Research conducted by 1st Internal Medicine Dept. of the Kyoto Pref. Medical University)
Other effects (Research conducted by Medical Research, Animal Experimentation, Saitama Medical College)
Acid control effect
Improvement effects on gastrointestinal problems
Investigation of safety through physical properties testing (Collaborative research by Graduate School of Medicine, Faculty of Medicine, Kyoto University and School of Engineering, Shiga Prefectural University)
Investigation of safety through animal safety testing (toxicity testing) (Research by Life Sciences Research Laboratory (GLP-conforming organization))
Clinical testing (Collaborative research by 2nd Internal Medicine Dept. of Shiga Medical University and Dept. of Gastroenterology, National Ohkura Hospital)
Investigation of effectiveness through animal effectiveness testing
・Intestinal fermentation suppression effect (Research conducted by Food Science Course, Faculty of Agriculture, Gifu University)
In testing with rats, the intestinal fermentation suppression effect of alkaline ionized water was confirmed under conditions with feed having plentiful intestinal fermentation.
In addition, the trend of reducing the malodorous metabolic products of ammonia, phenol, etc. in fecal matter and the effect of suppressing lipid peroxide in blood serum were also verified.
Comparison of total amount of short-chain fatty acids in appendix
(index of intestinal fermentation)
[Hayakawa: FOOD STYLE 21, Food Chemical Journal, Vol. 3, No. 2, pp. 49-55 (1999)]
[Hayakawa, et al: 7th Functional Water Symposium Tokyo Conference Program – Summary of Lectures, pp. 78-79 (2000)]
[Hayakawa, et al: Functional Water Research Vol. 1, No. 1, p. 45 (2002)]
・Calcium absorption effect (Research conducted by Graduate School of Medicine, Faculty of Medicine, Kyoto University)
It was verified that when rats that were raised on calcium-deficient feed drank alkaline ionized water, the calcium concentration in bones increased and bone formation was normalized, which suggested a link to osteoporosis prevention. In addition, the same effect was observed in animal testing using aging-induced mice, and it was verified that alkaline ionized water acted to reduce weakening of the bone structure.
Photograph of a rat on a calcium-deficient diet
[Itokawa: Japan Oral Functional Water Academics Society Journal, pp. 22-23 (2000)]
[Takahashi, et al: 6th Functional Water Symposium 1999 Tokyo Conference Program, Summary of Lectures, pp. 8-9 (1999)]
[Takahashi, et al: 7th Functional Water Symposium 2000 Tokyo Conference Program, Summary of Lectures, pp. 80-82 (2000)]
・Gastric mucous membrane damage suppression effect (Research conducted by 1st Internal Medicine Dept. of the Kyoto Pref. Medical University)
In testing using rats, it was verified that drinking alkaline ionized water suppressed gastric mucous membrane damage model (experimental disease induced by aspirin).
However, this effect was verified only in rats that continually drank alkaline ionized water. (There were no effects when the alkaline ionized water was given only once.)
Pathological observation of gastric mucus
[Yoshikawa, et al: “FRAGRANCE JOURNAL” March issue, pp. 14-17 (1999)]
[Naito, et al: “Functional Water Research” Vol. 1, No. 1, p. 43 (2002)]
[Y. Naito, T. Yoshikawa, et al: J. Clin, Blochem, Nutr., 43, 69-81 (2003)]
・Other effects (Research conducted by Medical Research, Animal Experimentation, Saitama Medical College)
It was verified that drinking alkaline ionized water provided a life-extending effect in mice and an effect of suppressing lipid peroxides in blood serum, which suggested the possibility of it also having anti-aging effects.
Long-term effects on mice
[Suzuki, et al: 8th Functional Water Symposium 2001 Osaka Conference Program, Summary of Lectures, pp. 34-35 (2001)]
[Nishina, et al: “Functional Water Research” Vol. 1, No. 1, p. 32 (2002)]
Investigation of effectiveness through clinical testing
(Collaborative research by 2nd Internal Medicine Dept. of Shiga Medical University and Dept. of Gastroenterology, National Ohkura Hospital)
・Antacid effect
6 volunteers from whom consent was received were given alkaline ionized water at pH9, pH10, and pH11 to drink (1L/day) and the results of measuring pH inside the stomach for 24 hours verified an increase in pH inside the stomach from drinking alkaline ionized water at pH9, which suggested an acid-control effect.
Intra-stomach pH fluctuation
・Improved effects against gastrointestinal symptoms
Patients with gastrointestinal symptoms (chronic diarrhea, constipation, abnormal fermentation in intestines, indigestion, acid indigestion, etc.) from whom consent was received were given alkaline ionized water at pH9.5 to drink for 2 weeks, and as a result, it was verified that there was an improvement in 88% of the 25 patients, and further, normalization of bowel movements was also verified.
Improved effects against gastrointestinal symptoms
For a more objective evaluation, the “double-blind comparison clinical test” was carried out. Patients with gastrointestinal symptoms from whom consent was received were given alkaline ionized water or purified water to drink for 4 weeks, and the resulting improvement effects were checked. The results revealed that alkaline ionized water was effective for the stomach and intestines, especially for relatively mild cases. The effectiveness for chronic diarrhea and constipation was also confirmed.
Improvement level in mild cases Improvement level of stool abnormalities
These clinical tests have proven the effectiveness of alkaline ionized water for the stomach and intestines. However, unlike medicine, there’s no promise of an immediate effect. Instead, it is thought that the daily consumption of alkaline ionized water can lead to gentle and gradual effects on the relatively mild cases. Alkaline ionized water must be consumed properly. (Alkaline ionized water is not always effective for all stomach and intestinal conditions.)
[Kitahora, et al: The Summary of “Electrolytic Water in Medical Treatment” at the symposium of the 25th General Assembly of the Medical Congress of Japan (1999)]
[Tashiro, et al: “Digestion and Absorption” issued by the Japan Digestion and Absorption Academics Society Vol. 23 No. 2, pp. 52-56 (2000)]
[Tashiro: P473-477, 5th Revision of the 32nd Edition of “Digestive Organs” published by Kagaku Hyoron Sha (2001)]
[Kitahora: Journal (T) of the 26th General Assembly of the Medical Congress of Japan (p. 33) (2003)]
[Itokawa: FOOD Style 21, Vol. 7, No. 8, pp. 81–83 (2003)]
Safety of alkaline ionized water
Since alkaline ionized water received approval as a medical device, they have been used for more than 30 years in the market. Although there have been no reported instances of problems with safety until now, it is necessary to continue performing sufficient investigations regarding its safety, and physical property tests and toxicity tests were performed prior to performing clinical testing.
In this section, the results of investigations into the safety of alkaline ionized water performed until now are briefly introduced.
・Investigation of safety through physical property testing
Collaborative research by Graduate School of Medicine, Faculty of Medicine, Kyoto University and School of Engineering, Shiga Prefectural University)
The electrodes, barrier membranes, and electrolysis promoters used were combined in various ways, and analysis of the byproducts, etc. in the generated alkaline ionized water such as the dissolved metals, trihalomethane, etc. was performed.
As a result of this analysis, no major problems in actual use were observed.
・Investigation of safety through animal safety testing (toxicity testing)
(Research by Life Sciences Research Laboratory (GLP-conforming organization))
As a result of testing by giving rats and crab-eating macaques alkaline ionized water to drink for short terms and long terms, no toxic influences such as harmful phenomenon, etc. were observed.
・Clinical testing
(Collaborative research by 2nd Internal Medicine Dept. of Shiga Medical University and Dept. of Gastroenterology, National Ohkura Hospital)
When alkaline ionized water at pH9.5 was drunk, no abnormalities in either subjective symptoms or objective symptoms were observed, and further, even for blood analysis, urinalysis, and stool analysis, no abnormal data caused by drinking alkaline ionized water were observed.
List of research reports related to alkaline ionized water
Reports from Alkaline Ionizer Review Committee
Researchers
Title of research
Source
Year
Yuji Naito, Toshikazu Yoshikawa, Nobuaki Yagi, Masahiro Arai, Kiichi Matsuyama, Motoharu Kondo Investigation of effectiveness of functional water against experimental gastric mucous membrane damage Functional Water Symposium '94 Program/Preliminary Proceedings, pp. 6-9 1994
Chen Hui Jun, Zhu Zong Jian, Mieko Kimura, Yoshinori Itokawa Evaluation of ionized calcium as a calcium nutrient source Japan Trace Nutrients Research Society Abstracts Collection, p. 19 1994
Haruhito Tsuge, Misako Mori, Seiji Hayashi, Takashi Hayakawa Physiological effects of alkaline ionized water (I) Japanese Society of Nutrition and Food Science Abstracts Collection, p. 244 1995
Satsuki Segawa, Seiji Hayashi, Takashi Hayakawa, Haruhito Tsuge Physiological effects of alkaline ionized water (II) Japanese Society of Nutrition and Food Science Abstracts Collection, p. 244 1995
Kenji Kikuchi, Yoshiro Tomita, Zempachi Ogumi Electrolysis conditions of alkaline ionized water apparatus and formation of electrolytic water Electrolysis Technology Conference, 19th Soda Industrial Technology Conference, Abstracts Collection, pp. 50-53 1995
Zhang Zhen Hua, Mieko Kimura, Yoshinori Itokawa Influence of alkaline ionized water on rat bone volume Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.10-11
1995
Soichiro Miura, Han Jing Yan, Hajime Higuchi, Iwao Kurose, Hiromasa Ishii Influence of alkaline ionized water on microcirculation of small intestine Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.12-13 1995
Takashi Hayakawa, Satsuki Segawa, Misako Mori, Seiji Hayashi, Haruhito Tsuge Physiological effects of alkaline ionized water: Animal effectiveness testing using rats Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.14-15 1995
Yuji Naito, Toshikazu Yoshikawa, Masahiro Arai, Norimasa Yoshida, Motoharu Kondo Investigation of alkaline ionized water effectiveness on experimentally induced gastric mucous membrane damage Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.16-17 1995
Yoshihide Fujiyama, Kenichi Sumiyoshi, Tadao Baba Effects of alkaline ionized water on non-specific abdominal complaints Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.18-19 1995
Hirokazu Tashiro, Tetsuji Kitahora, Yoshihide Fujiyama, Kenichi Sumiyoshi, Tadao Baba Fundamental clinical testing of alkaline ionized water Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.20-21 1995
Zempachi Ogumi, Yoshiro Tomita, Kenji Kikuchi Electrolytic conditions of tap water and formation of electrolytic water Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.56-57 1995
Atsunobu Matsuo, Hitoshi Yamamoto, Nobuaki Arai, Takeshi Hisa, Motohiro Nishikawa, Noriko Matsuto, Yokazu Matsushima, Shigeru Morita, Yukio Yanagimoto Alkaline ionized water safety evaluation I: Investigation of repetitive oral administration of alkaline ionized water to rats for 1 month and 6 months Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.58-59 1995
Hitoshi Yamamoto, Atsunobu Matsuo, Hideki Hashimoto, Yasuhiko Goto, Akitsugu Ikeda, Yokazu Matsushima, Shigeru Morita, Yukio Yanagimoto Alkaline ionized water safety evaluation II: Investigation of repetitive oral administration of alkaline ionized water to crab-eating macaques for 4 weeks Functional Water Symposium '95 Kyoto Conference Preliminary Proceedings, pp.60-61 1995
Yoshiro Tomita, Kenji Kikuchi, Zempachi Ogumi Electrolytic conditions of tap water and formation of electrolytic water (focusing on trihalomethane countermeasures) 63rd Japan Society for Analytical Chemistry and Organic Microanalysis Research Society Joint Symposium Abstracts Collection, pp. 59-64 1996
Yuji Naito, Takaaki Fujii, Toshikazu Yoshikawa, Motoharu Kondo Investigation of alkaline ionized water effects on damage to gastric mucous membrane cultured cells due to activated oxygen Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, pp.46-47 1996
Haruhito Tsuge, Nami Sugiyama, Naomi Katayama, Takashi Hayakawa Relationship between alkaline ionized water intake and ORP (oxygenation reduction potential) Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, pp.116-117 1996
Zhang Zhen Hua, Mieko Kimura, Yoshinori Itokawa Influence of alkaline ionized water on minerals in rat bodies Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, p.118 1996
Kenichi Sumiyoshi, Yoshihide Fujiyama, Tadao Baba, Hirokazu Tashiro, Tetsuji Kitahora Long-term clinical testing of alkaline ionized water Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, pp.120-121 1996
Tetsuji Kitahora Evaluation of drinking water functionalization: Investigation through alkaline ionized water Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, p.5 1996
Toshikazu Yoshikawa Medical care and functional water Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, p.6 1996
Zempachi Ogumi, Minoru Inaba, Toru Kuroe, Kenji Kikuchi Gas-generating reaction at electrodes and its solubility 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, pp. 7-8
1997
Kenji Kikuchi, Hiroko Takeda, Takuji Okaya, Zempachi Ogumi Oversaturation phenomenon in alkaline electrolytic water 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, pp. 9-10 1997
Zhang Zhen Hua, Rei Takahashi, Yoshinori Itokawa Influence of alkaline ionized water on bone formation in rats 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, p. 11 1997
Yuji Naito, Toshikazu Yoshikawa, Takaaki Fujii, Yoshio Boku, Motoharu Kondo Gastric mucous membrane damage due to activated oxygen: Does alkaline ionized water possess a cell protective action? 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, pp. 12-13 1997
Hirokazu Tashiro, Hiromi Ono, Tetsuji Kitahora Influence of drinking alkaline ionized water on activated oxygen 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, pp. 14-15 1997
Toshikazu Yoshikawa Recent Advance in Experimental and Clinical Reseach on Alkaline Ionized Water in Japan 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, p. 81 1997
Kenji Kikuchi, Hiroko Takeda, Takuji Okaya, Zempachi Ogumi Analysis of hydrogen oversaturation in electrolytic water Electrochemical Society of Japan 65th Conference Abstracts Collection, p. 48 1998
Kenji Kikuchi, Hiroko Takeda, Beatrice Rabolt, Takuji Okaya, Zempachi Ogumi, Yasuhiro Saihara, Hiroyuki Noguchi Reduction activities and stability of oversaturated hydrogen gas molecules in electrolytic water 5th Functional Water Symposium '98 Yokohama Conference Program/Preliminary Proceedings, pp. 62-63 1998
Yoshihide Fujiyama, Shigeki Koyama, Tadao Baba Alkaline ionized water and irritable gut (NUD/IBS) 5th Functional Water Symposium '98 Yokohama Conference Program/Preliminary Proceedings, pp. 65-66 1998
Yuji Naito, Toshikazu Yoshikawa, Nobuaki Yagi, Kiichi Matsuyama Investigation of alkaline ionized water effectiveness on gastric mucous membrane damage due to non-steroidal anti-inflammation medicines 5th Functional Water Symposium '98 Yokohama Conference Program/Preliminary Proceedings, pp. 67-68 1998
Takashi Hayakawa, Keiko Nonoyama, Kisui Isaji, Haruhito Tsuge Intake effect of alkaline ionized water: Influences on intestinal fermentation and feeding conditions 5th Functional Water Symposium '98 Yokohama Conference Program/Preliminary Proceedings, pp. 69-70 1998
Zempachi Ogumi, Kenji Kikuchi, Hirokazu Tashiro, Tetsuji Kitahora, Yoshihide Fujiyama, Tadao Baba, Toshikazu Yoshikawa, Yuji Naito, Motoharu Kondo, Takashi Hayakawa, Haruhito Tsuge, Rei Takahashi, Zhang Zhen Hua, Yoshinori Itokawa Fundamentals and effective utilization of alkaline ionized water:
・Validation of effective use of alkaline ionized water
・Characteristics and safety of alkaline ionized water
・Clinical investigations of alkaline ionized water
・Investigation of effectiveness of alkaline ionized water on gastric mucous membrane damage
・Influences of alkaline ionized water on intestinal fermentation
・Influences of alkaline ionized water on bone formation
25th Japan Association of Medical Sciences Symposium, "Electrolytic Functional Water in Medical Treatment", Summary Collection 1999
Kenji Kikuchi, Takuji Okaya, Zempachi Ogumi, Yasuhiro Saihara Physiological characteristics of alkaline ionized water 1999 Japanese Association for Animal Cell Technology Conference Summary Collection, p. 22 1999
Rei Takahashi, Zhang Zhen Hua, Yoshinori Itokawa Influence of alkaline ionized water on bone formation in rats 5th Functional Water Symposium '98 Yokohama Conference Program/Preliminary Proceedings, pp. 71-72 1998
Hirokazu Tashiro, Tetsuji Kitahora, Hiromi Ono, Yoshihide Fujiyama, Tadao Baba Investigation of effectiveness of alkaline ionized water on intestinal complaints: Double-blind testing 6th Functional Water Symposium '99 Tokyo Conference Program/Abstracts Collection, pp. 6-7 1999
Rei Takahashi, Zhang Zhen Hua, Yoshinori Itokawa Influences of alkaline ionized water on formation and maintenance of bone structure 6th Functional Water Symposium '99 Tokyo Conference Program/Abstracts Collection, pp. 8-9 1999
Yuji Naito, Toshikazu Yoshikawa, Tomohisa Takagi, Tsuyoshi Ishikawa, Osamu Handa, Naoyuki Matsumoto, Kiichi Matsuyama, Nobuaki Yagi, Norimasa Yoshida, Motoharu Kondo Effects of alkaline ionized water on gastric mucous membrane damage due to aspirin 6th Functional Water Symposium '99 Tokyo Conference Program/Abstracts Collection, pp. 10-11 1999
Takashi Hayakawa, Chieko Tsuchitani, Hisaki Onoda, Hisayo Okochi, Haruhito Tsuge Physiological effects of alkaline ionized water: Effects on intestinal products 6th Functional Water Symposium '99 Tokyo Conference Program/Abstracts Collection, pp. 12-13 1999
Kenji Kikuchi, Hiroko Takeda, Beatrice Rabolt, Takuji Okaya, Zempachi Ogumi, Yasuhiro Saihara, Hiroyuki Noguchi Physiological characteristics of alkaline ionized water 6th Functional Water Symposium '99 Tokyo Conference Program/Abstracts Collection, pp. 14-15 1999
Takashi Hayakawa Functions and applications of alkaline ionized water Food Style 21, Food Science Newspaper, Vol. 3, No. 2, pp. 49-55 1999
Hirokazu Tashiro, Tetsuji Kitahora Alkaline ionized water and gastrointestinal symptoms: Effects on activated oxygen Treatment, Vol. 81, No. 1, pp. 132-134 1999
Toshikazu Yoshikawa, Yuji Naito, Motoharu Kondo Influences of alkaline ionized water on gastric functions and suppressive actions against gastric mucous membrane damage Fragrance Journal, March issue, pp. 14-17 1999
Yuji Naito, Toshikazu Yoshikawa, Tomohisa Takagi, Nobuaki Yagi, Kiichi Matsumoto, Norimasa Yoshida, Motoharu Kondo Gastric mucous membrane protective actions of alkaline ionized water and gastric acid secretion Japanese Society of Gastric Secretion Research Magazine, Vol. 31, pp. 69-72 1999
Yoshinori Itokawa Functional water and health: Considerations regarding alkaline ionized water research results Japan Society for Oral Functional Water Magazine, pp. 22-23 2000
Kenji Kikuchi, Takuji Okaya, Beatrice Rabolt, Hiroko Takeda, Zempachi Ogumi, Yasuhiro Saihara Oversaturated hydrogen density in cathodic electrolyzed water and electrolytic conditions Electrochemical Society of Japan 67th Conference Abstracts Collection, p. 195 2000
Yoshihide Fujiyama, Shigeki Koyama, Tadao Baba, Hirokazu Tashiro, Hiromi Ono, Tetsuji Kitahora Clinical experiments with alkaline ionized water 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp. 74-75 2000
Yuji Naito, Tomohisa Takagi, Naoya Tomatsuri, Tsuyoshi Ishikawa, Osamu Handa, Kiichi Matsuyama, Norimasa Yoshida, Toshikazu Yoshikawa Gastric mucous membrane protective mechanism of alkaline ionized water: Clarification of that mechanism 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.76-77 2000
Takashi Hayakawa, Hisayo Okochi, Takao Shimakura, Chieko Tsuchitani, Haruhito Tsuge Physiological effects of alkaline ionized water: Suppression of large-intestine fermentation and reduction of harmful product generation 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.78-79 2000
Rei Takahashi, Zhang Zhen Hua, Yoshinori Itokawa Effects of alkaline ionized water on bone formation and maintenance 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.80-82 2000
Kenji Kikuchi, Takuji Okaya, Zempachi Ogumi, Yasuhiro Saihara, Hiroyuki Noguchi Physiological characteristics of alkaline ionized water 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.84-85 2000
Hirokazu Tashiro, Tetsuji Kitahora, Yoshihide Fujiyama, Tadao Baba Clinical investigation of effectiveness of alkaline ionized water on chronic diarrhea: Double-blind placebo control study Japanese Society of Digestion and Absorption, "Digestion and Absorption", Vol. 23, No. 2, pp. 52-56 2000
Tetsuji Kitahora Fundamentals of alkaline ionized water: Effects and caution points Summer Functional Water Symposium 2001, pp. 15-16 2001
Hirokazu Tashiro Usefulness of alkaline ionized water against chronic diarrhea Gastroenterology, Vol. 32, No. 5, pp. 473-477, Kagaku Hyoronsha 2001
Kenji Kikuchi,Hiroko Takeda,Beatrice Rabolt,Takuji Okaya,Zempachi Ogumi,Yasuhiro Saihara,Hiroyuki Noguchi Hydrogen Particles and supersaturation in alkaline water from an Alkali-Ion-Water electrolyzer Journal of Electroanalytical Chemistry,Vol.506(1),p22-27 2001
Tetsuji Kitahora Fundamentals of alkaline ionized water: Effects and caution points Summer Functional Water Symposium 2001, 10th Functional Water Medical Research Conference, and 22nd Water Research Committee Seminar Joint Conference, pp. 15-16 2001
Hirokazu Tashiro Usefulness of alkaline ionized water against chronic diarrhea Gastroenterology, Vol. 32, No. 5, pp. 473-477, Kagaku Hyoronsha 2001
Zempachi Ogumi Science of alkaline ionized water: From physical chemistry aspect 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp. 24-25 2001
Tetsuji Kitahora Science of alkaline ionized water: From clinical application aspect 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp. 26-27 2001
Kenji Kikuchi, Takuji Okaya, Beatrice Rabolt, Zempachi Ogumi, Yasuhiro Saihara, Hiroyuki Noguchi Dissolved hydrogen and reduction activities of alkaline ionized water 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp. 28-29 2001
Rei Takahashi, Kenji Kikuchi, Zhang Zhen Hua, Hiroyuki Noguchi, Yoshinori Itokawa Analysis of physiological functions of alkaline ionized water using human cultured cells 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp. 30-31 2001
Takashi Hayakawa, Takao Shimakura, Shunsuke Mikasa, Haruhito Tsuge Physiological effects of alkaline ionized water: Influences on intestinal fermentation products and blood components 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp. 32-33 2001
Kenji Kikuchi,Hiroko Takeda,Beatrice Rabolt,Takuji Okaya,Zempachi Ogumi,Yasuhiro Saihara,Hiroyuki Noguchi Hydrogen concentration in water from an Alkali-Ion-Water electrolyzer having a platinum-electroplaterd titanium electrode Journal of Applied Electrochemistry 31;1301-1306 2001
Kenji Kikuchi Fundamentals of electrolytic functional water High-Technology Medicine 2001, p. 135 2002
Tetsuji Kitahora Alkaline ionized water High-Technology Medicine 2001, p. 137 2002
Takao Shimakura, Takashi Hayakawa, Haruhito Tsuge Physiological effects of alkaline ionized water: Influences on intestinal fermentation products and peroxidized lipids in blood serum Japanese Society of Nutrition and Food Science Abstracts Collection, p. 269 2002
Kenji Kikuchi, Takuji Okaya, Yoshinori Tanaka, Yasuhiro Saihara, Zempachi Ogumi Existence and characteristics of oversaturated hydrogen in alkaline electrolytic water Functional Water Research Vol. 1, No. 1, p. 25 2002
Miho Maeda, Kenji Kikuchi, Takuji Okaya, Yoshinori Tanaka, Yasuhiro Saihara, Zempachi Ogumi Lipids: Distribution of hydrogen gas in water Functional Water Research Vol. 1, No. 1, p. 26 2002
Atsunobu Matsuo, Hitoshi Yamamoto, Yukio Yanagimoto Experimental evaluation of alkaline ionized water toxicity Functional Water Research Vol. 1, No. 1, p. 31 2002
Masami Nishina, Nobuko Tominaga, Kazuhiro Matsushita, Wen Xian De, Masahiko Suzuki, Masami Suzuki Effects of drinking alkaline ionized water on skin structure water in the growth process of mice Functional Water Research Vol. 1, No. 1, p. 32 2002
Shunsuke Mikasa, Takashi Hayakawa, Haruhito Tsuge Influence of alkaline ionized water intake on the immune system Functional Water Research Vol. 1, No. 1, p. 33 2002
Yoshihide Fujiyama, Tetsuji Kitahora, Yoshinori Itokawa Alkaline ionized water and digestive organ function problems Functional Water Research Vol. 1, No. 1, p. 42 2002
Yuji Naito, Tomohisa Takagi, Kazuhiko Uchiyama, Naoya Tomatsuri, Norimasa Yoshida, Toshikazu Yoshikawa Chronic dosage of alkaline ionized water as a medical treatment against Tumor Necrosis Factor (TNF)-α Functional Water Research Vol. 1, No. 1, p. 43 2002
Rei Takahashi, Kenji Kikuchi, Zhang Zhen Hua, Hiroyuki Noguchi, Yoshinori Itokawa Analysis of alkaline electrolytic water functions on human cultured cells Functional Water Research Vol. 1, No. 1, p. 44 2002
Takashi Hayakawa, Takao Shimakura, Haruhito Tsuge Physiological effects of alkaline ionized water: Influences and feeding conditions on fermentation in appendix and serum lipid peroxide levels Functional Water Research Vol. 1, No. 1, p. 45 2002
Masami Suzuki, Nobuko Tominaga, Masami Nishina, Masahiko Suzuki Influences of drinking alkaline ionized water on mouse growth process Functional Water Research Vol. 1, No. 1, p. 46 2002

Examples of reports from other researchers
Researchers
Title of research
Source
Year
Watanabe T,
Shirai W
Influence of alkaline ionized water on reproductive functions in the rats Journal of Japanese Society of Fertility and Sterility, Vol. 35, No. 4, pp. 748-751 1990
Motoyuki Suzuki, Kazuhiro Ichikawa, Yasuyuki Sakai Influences of functional water on cell culture Journal of Water Re-use Technology, Vol. 20, No. 3 1993
Noriyuki Sawa, Kaori Miyai, Kazue Mifune Influences of alkaline ionized drinking water on broiler productivity Tokushima Prefecture Animal Husbandry Bulletin, No. 35, pp. 82-84 1995
Takao Kato, Kanako Igarashi, Katsumi Masuda, Masahachi Tani Influences of water quality on enzymatic activity of natto (fermented soybeans) fermentation (Report #1) Jin-ai Women's College Research Bulletin, Vol. 27, pp. 43-49 1995
Tsuyoshi Takiguchi, Takahiro Yamazaki, Kazuhiro Kubota, Yukie Sato Regarding use of acidic water and alkaline ionized water in tofu production Gunma Industrial Laboratories Research Bulletin, pp. 96-101 1994
Hideyuki Karasawa, Nobuyuki Muramatsu, Hiroshi Obinata, Shoji Kaneko Research regarding the suitability of alkaline ionized water for tofu production Nagano Food Laboratories Bulletin 23, pp. 53-56 1995
Watanabe T Effects of alkaline ionized water on reproduction in gestational or lactational rats Journal of Japanese Society of Fertility and Sterility, Vol.20,No.2,pp. 135-142 1995
Takeshi Ishii, Hironori Okamoto Utility of alkaline ionized water and acidic water for mice Water Treatment Technology, Vol. 36, No. 12, pp. 603-608 1995
Satoru Tamaki, Kazuhito Yokyama, Takeshi Tanigawa, Jin Zhen Wan, Shunichi Araki Influences of functional water on predisposition to diabetes: Forecast Functional Water Symposium '94 Program/Preliminary Proceedings, pp. 9-12 1994
Takeshi Tanigawa, Shunichi Araki一 Influences of functional water on immune system Functional Water Symposium '94 Program/Preliminary Proceedings, pp.13-15 1994
Hirogazu Nishimura, Takako Shinkai Utility of weakly basic electrolytically generated aqueous solution or acidic electrolytically generated aqueous solution for atopic dermatitis Functional Water Symposium '94 Program/Preliminary Proceedings, pp.21-24 1994
Yukinori Sato, Shun Noguchi, Setsuko Takahashi, Fumiko Naito State of rice cooked with electrolytic water and immersed state of rice Japan Society of Home Economics Magazine, Vol. 45, No. 4, pp. 343-348 1994
Masahiko Suzuki, Masami Nishina, Tomoya Kuramochi, Yukiko Yamakawa, Katsuhiro Yabe, Masami Suzuki Does alkaline ionized water prevent the onset of hypertension? Medicine and Biology, Vol. 131, No. 6, pp. 249-252 1995
Masahiko Suzuki, Masami Nishina, Tomoya Kuramochi, Yukiko Yamakawa, Katsuhiro Yabe, Masami Suzuki Anti-hypertensive effect of enalapril in spontaneously hypertensive rats drinking alkaline ionized water Medicine and Biology, Vol. 131, No. 6, pp. 281-286 1995
Koichiro Kameyama Application of alkaline ionized water and super-oxygenated water for atopic dermatitis Bioscience and Industry, Vol. 53, No. 1, pp. 34-36 1995
Masahiko Suzuki, Masami Nishina, Tomoya Kuramochi, Yukiko Yamakawa, Katsuhiro Yabe, Masami Suzuki Anti-hypertensive effect of enalapril in spontaneously hypertensive rats drinking alkaline ionized water Medicine and Biology, Vol. 131, No. 6, pp. 281-286 1995
Masahiko Suzuki, Masami Nishina, Tomoya Kuramochi, Yukiko Yamakawa, Katsuhiro Yabe, Masami Suzuki Does alkaline ionized water prevent the onset of hypertension? Medicine and Biology, Vol. 131, No. 6, pp. p249-252 1995
Takeo Inamasu, Hitomi Hayabuchi, Kosaku Noda Regarding sensory evaluation testing of green tea prepared with alkaline ionized water and the eluted amount of tea components by elution testing Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, pp.110-111, 1996
Toshihiro Yamagishi, Akiko Kikuchi, Hisashi Shinohara, Yukiko Otomo, Akira Nishida Influences of drinking electrolytic water on the growth, blood composition, and accumulation of body fat of hamsters Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, pp.112-113 1996
Takeshi Okada, Setsuo Sano, Masanori Takashi, Kazuko Eguchi Treatment experiences when treating treatment-resistant atopic dermatitis with weakly acidic electrolytic water and alkaline ionized water Functional Water Symposium '96 Fukuoka Conference Program/Preliminary Proceedings, pp.78-79 1996
Sanetaka Shirahata, Kenichi Kusumoto, 証屋輝一郎, Kazuhiro Aida, Masaaki Oda, Miho Goto, Shigeru Kabayama, Shinkatsu Morisawa, Kazumichi Otsubo, Hidemitsu Hayashi, Yoshinori Katakura Activated oxygen elimination effect of electrolytic reduced water and its influence on intracellular signaling 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, pp. 16-17 1997
Masahiko Suzuki, Masami Nishina, Michie Tezuka, Nobuko Tominaga, Masami Suzuki, Kazuhiro Matsushita, Kenzo Kato Influences of alkaline electrolytic water on the onset of hypertension in Dahl salt-sensitive rats 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, pp. 103-104 1997
G.Fernandes,
J.DeVierville,
D.Nelson
Effect of Reduced Water Intake on Lifespan of Autoimmune Disease Prone Mice 4th Functional Water Symposium '97 Tokyo Conference Program/Preliminary Proceedings, p. 73 1997
Watanabe T,Shirai W,Kishikawa Y Influence of alkaline ionized water on rat erythrocyte hexokinase activity and the myocardium J. Toxicol Sci.Vol.22,No.2,p141-152 1997
Kenji Kobayashi, Yukikazu Yamasaki, Noriteru Tosa, Yasuo Hara, Shuji Horie Effects of electrolytic water for extraction of dried bonito extract components Japanese Society for Food Science and Technology Magazine, Vol. 44, No. 7, pp. 508-511 1997
Kenji Kobayashi, Noriteru Tosa, Yasuo Hara, Shuji Horie Investigation of rice cooking characteristics of electrolytic water Japanese Society for Food Science and Technology Magazine, Vol. 43, No. 8, pp. 930-937 1997
S.Shirahata, S.Kabayama, M.Nakano, T.Miura, K.Kusumoto, M.Gotoh, H.Hayashi, K.Otsubo, S.Morisawa, and Y.Katakura Electrolyzed-Reduced Water Scavenges Active Oxigen Species and Protect DNA from Oxidative Damage BBRC234,p269-274 1997
Masahiko Suzuki, Masami Nishina, Masami Suzuki, Michie Tezuka, Nobuko Tominaga, Kenzo Kato Hypertension and alkaline ionized water 5th Functional Water Symposium '98 Yokohama Conference Program/Preliminary Proceedings, pp. 73-74 1998
Gabriel Fernandes Effects of alkaline ionized water on free radicals and antioxidation enzymes 5th Functional Water Symposium '98 Yokohama Conference Program/Preliminary Proceedings, p.49 1998
Atsuko Nakagawa, Masamichi Koseki, Junko Sekita, Yuka Nojima, 石井秀 Cooking vegetables with alkaline ionized water New Food Industry,Vol.40,No.7,p61-64 1998
Hidekazu Nara, Hiroaki Kubota, Kazuo Miyashita, Toru Ota, Tetsuya Suzuki Anti-oxidation effects of anode electrolytic water: Effects on squalene and ribosomes Petrochemical Studies Proceedings, Vol. 37, p. 60 1998
Sanetaka Shirahata, Shigeru Kabayama, Kazuhiro Nagata Cutting-edge of food allergies: Food components and allergies -- Immune system adjustment actions due to foods Journal of Clinical and Experimental Medicine, Special October Edition, pp. 51-56 1999
Hidekazu Nara, Hiroaki Kubota, Kazuo Miyashita, Tetsuya Suzuki, Hidetaka Kobayashi, Akihiko Nagao Explanation of anti-oxidation mechanism of anode electrolytic water and oxidation-suppression effects against various carotenoids Petrochemical Studies Abstracts Collection, Vol. 38, p. 6 1999
Miyashita, M.Yasuda, T.Ota, T.Suzuki Antioxidative Activity of a Cathodic Solution Produced by the Electrolysis of a Dilute NaCl Solution Biosci. Biotechnol. Biochem.,63 (2),421-423 1999
Munenori Kawamura Application of reduced water to medical treatment 1999 Japanese Association for Animal Cell Technology Abstracts Collection, 24 1999
Sanetaka Shirahata Cancer-suppression effects and anti-diabetic effects of reduced water 1999 Japanese Association for Animal Cell Technology Abstracts Collection, 25 1999
Sanetaka Shirahata Physiological functions of water Journal of the Japanese Forestry Society, Vol. 74, No. 1, pp. 165-171 1999
Sanetaka Shirahata Animal cell function control due to reduced water and its utility for medical treatment Journal of Japan Society for Bioscience, Biotechnology, and Agrochemistry, Vol. 74, No. 9, pp. 994-998 2000
Masami Suzuki, Masahiko Suzuki, Masami Nishina, Nobuko Tominaga Influences of long-term drinking of alkaline water on mouse growth process 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.82-83 2000
Tetsuya Suzuki Fundamental analysis of strongly alkaline electrolytic water 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.12-13 2000
Kenji Fukunaga, Masumi Watanabe, Kazuo Miyashita, Tetsuya Suzuki Does strongly alkaline reduced water exhibit a reducing power? 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.14-15 2000
Kenji Kikuchi Electrochemical reaction of anodic water electrolysis 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.16-17 2000
Takehisa Nakayama, Kunimoto Hotta, Masahiro Kono ESR analysis of strongly alkaline electrolytic water 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.18-19 2000
Kazuo Miyashita, Yuriko Toge, Hiroaki Kubouchi Lipid extraction effects and anti-oxidation activity of strongly alkaline electrolytic water 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.20-21 2000
Kenji Kurata Does anode electrolytic water suppress photoinhibition of plants? 7th Functional Water Symposium 2000 Tokyo Conference Program/Abstracts Collection, pp.22-23 2000
Tomoaki Matsumoto Reduction of wheat gluten allergens using electrolysis reduction processing Food Processing and Ingredients, Vol. 35, No. 10, pp. 5-7 2000
Sanetaka Shirahata Animal cell function control due to reduced water and its utility for medical treatment Journal of Japan Society for Bioscience, Biotechnology, and Agrochemistry, Vol. 74, No. 9, pp. 994-998 2000
Sanetaka Shirahata Characteristics of reduced water having activated oxygen elimination functions and its physiological functions 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp. 64-65 2001
Kazuo Miyashita, Hiroaki Kubouchi, Hidekazu Nara, Tetsuya Suzuki Anti-oxidation activity of strongly alkaline electrolytic water 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp.66-67 2001
Kenji Kobayashi, Masashi Inada, Tsutomu Asano, Kosuke Shintani, Yasusuke Hara, Koichi Takinami, Yoshikazu Izumi Reducing power and effects on dissolved oxygen due to the antioxidant activity of alkaline electrolytic water 8th Functional Water Symposium 2001 Osaka Conference Program/Abstracts Collection, pp.68-69 2001
K.Hanaoka Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions Journal of Applied Electrochemistry 31;1307-1313 2001
Takafumi Kato, 山田和, Shinkatsu Morisawa, Hidehiko Yokogoshi Fundamental research into anti-oxidation performance using electrolyzed reduced water and its influences on living bodies Japanese Society of Nutrition and Food Science Abstracts Collection, p. 269 2002
Masamichi Koseki, Atsuko Nakagawa, Hironobu Seki, Shoko Shinoda Influences of alkaline ionized water intake on serum triglyceride levels of rats Functional Water Research Vol. 1, No. 1, p. 30 2002